KEGG   Homo sapiens (human): 2899
Entry
2899              CDS       T01001                                 
Symbol
GRIK3, EAA5, GLR7, GLUR7, GluK3, GluR7a
Name
(RefSeq) glutamate ionotropic receptor kainate type subunit 3
  KO
K05203  glutamate receptor, ionotropic kainate 3
Organism
hsa  Homo sapiens (human)
Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
Drug target
Dasolampanel: D10107
Dasolampanel etibutil: D10108
Dasolampanel etibutil tosylate: D10109
Riluzole: D00775<JP/US>
Tezampanel: D06656
Topiramate: D00537<JP/US>
Troriluzole (DG03011): D11414 D11415
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2899 (GRIK3)
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    2899 (GRIK3)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    2899 (GRIK3)
Ion channels [BR:hsa04040]
 Ligand-gated channels
  Glutamate (ionotropic)
   2899 (GRIK3)
SSDB
Motif
Pfam: ANF_receptor Lig_chan Lig_chan-Glu_bd SBP_bac_3 Peripla_BP_6
Other DBs
NCBI-GeneID: 2899
NCBI-ProteinID: NP_000822
OMIM: 138243
HGNC: 4581
Ensembl: ENSG00000163873
UniProt: Q13003
Position
1:complement(36795527..37034515)
AA seq 919 aa
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
NT seq 2760 nt   +upstreamnt  +downstreamnt
atgaccgctccctggcggcgcctccggagtctggtttgggaatactgggccgggctcctc
gtgtgcgccttctggatcccggactcgcgcgggatgccccacgtcatccggatcggagga
atcttcgagtatgcggacggccccaacgcccaggtcatgaatgccgaggagcatgccttt
cgattttctgccaacatcatcaacaggaacaggactctgctgcccaacacaaccttgacc
tatgacatacagaggattcacttccatgacagcttcgaggcgaccaaaaaggcctgtgac
cagctggcactgggcgtggtggcgatcttcggcccatcacagggctcctgcaccaatgcc
gtccagtccatctgcaatgccctggaggtgccccacatccagctgcgttggaagcaccac
ccgctggacaacaaggacaccttctacgtgaacctctaccccgactacgcctcgctcagc
catgccatcctcgacctggtccagtacctcaagtggcggtcagccaccgtggtctatgac
gacagtacagggctcatccgactgcaggagctcatcatggccccatcaagatacaacatc
cgcctgaagatccgtcagctccccatcgactctgacgactcgcgccccttgctcaaggag
atgaagcgaggccgggaattccgcattatcttcgactgcagccacactatggcggcccag
atcctcaagcaggccatggccatgggcatgatgactgagtactaccacttcatcttcacc
actctggatctctacgctttagacctggagccctaccgctactcaggcgtgaacctgaca
ggattccggattctcaatgtggacaacccacacgtctcggccattgtggagaagtggtcc
atggagcggctgcaggcagctccccggtccgagtctggcctgctggatggagtgatgatg
actgatgcagccttactgtacgacgccgtccatatcgtgtccgtgtgctaccagcgggca
ccacagatgaccgtgaactccctgcagtgccatcggcacaaggcctggcgctttggcggc
cgcttcatgaacttcatcaaggaggctcaatgggaaggattaactggacgaattgttttc
aacaaaactagtggcttgcggacggattttgatctggacatcatcagcctgaaagaggat
ggcctggagaaggttggggtgtggagtcctgccgacgggctcaacatcactgaggttgcc
aaaggccgaggccctaatgtcaccgactctctgacaaacagatcactcattgtcaccaca
gtgctggaggagcccttcgtcatgtttcggaaatcagacaggacgctatacgggaatgac
cggttcgagggctactgcatcgacctgctaaaggagctggcccacatccttggtttctcc
tatgagatccggctggtggaggacggcaagtacggggcacaggatgacaagggccagtgg
aacggcatggtcaaggagctcatcgaccacaaggcagatctggccgtggcccccctgacc
atcacccatgttcgagagaaggccatcgacttctccaagcccttcatgacacttggtgtg
agcatcctgtatcgaaagcccaatggcaccaaccccagcgtcttctccttcctcaatccc
ctgtccccagacatctggatgtatgttctcctcgcctacctgggggtcagctgtgtcctc
ttcgtcatcgccaggttcagcccttatgagtggtacgatgctcacccctgcaaccctggc
tccgaggtggtggaaaataacttcactctgcttaacagcttctggtttggaatgggatcc
ctgatgcagcaagggtctgagctgatgcccaaagccctgtccacacgcatcattggtggc
atctggtggttcttcacgctcatcatcatctcttcctacacggccaacctggctgccttt
ctgaccgtggagcgcatggaatcacccattgactctgctgatgacctggccaagcaaacc
aaaatcgagtatggggctgtcaaggatggggccaccatgaccttcttcaagaaatccaag
atctccaccttcgagaagatgtgggccttcatgagcagcaagccatcggcgctggtgaag
aacaacgaggagggcatccagagggccctgacggccgactacgcgctgctcatggagtcc
accaccatcgagtacgtcacgcagaggaactgcaacctcacccagatcgggggcctcatt
gactccaagggctacggcatcggcacgcccatgggctccccataccgggacaagatcacc
atcgccatcctgcagcttcaggaggaggacaagctgcatatcatgaaggagaagtggtgg
cggggcagcgggtgtcctgaggaggaaaacaaagaggccagtgccctggggatccagaag
atcgggggcatcttcattgtcctggccgccgggctggtcctctctgtgctggtggccgtg
ggcgagtttgtgtacaagctccgcaaaacagcagagagagagcagcgttccttctgcagc
accgtggccgatgagatccgtttctcccttacctgccagcgtcgagtcaagcacaagcct
cagcctcccatgatggtcaagactgacgccgtcatcaacatgcacacattcaatgaccgc
cggcttcccggcaaggacagcatggcctgcagcacatccttagcccctgtgttcccctag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   OMIM (1)   
Drug (8)   
   KEGG DRUG (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
Protein domain (5)   
   Pfam (5)   
All databases (52)   

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